The elusiveness of polymer knots
Physics Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Corresponding author: a email@example.com
Revised: 8 November 2007
Published online: 19 December 2007
Knots are a topological property of closed curves, and while not rigorously defined, are also expected to occur in sufficiently long open polymers. We argue, however, that energetic and entropic factors favor tight knots, with the entanglements localized on relatively small segments. Knots are statistically rare in swollen (coil) polymers, but abundant in compact (globular) configurations. Yet, our investigation of the Protein Data Bank reveals very few knotted structures in globular proteins. We shall discuss some particularly intriguing examples of this set, including the most complicated protein knot appearing in Human ubiquitin hydrolase.
PACS: 36.20.Ey – Conformation (statistics and dynamics) / 02.10.Kn – Knot theory
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag, 2008