https://doi.org/10.1140/epjb/e2004-00105-2
Evolutionary stabilization of generous replicases by complex formation
Fraunhofer – Biomolecular Information Processing Schloss Birlinghoven, St. Augustin 53754, Germany
Corresponding author: a rudolf.fuechslin@biomip.fhg.de
Received:
17
December
2003
Published online:
20
April
2004
The importance of spatial organization for the evolutionary stability of
trans-acting replicase systems (
,
where T is a general member of a combinatorial family including the special
catalyst X, is now well established, by analytical and Monte Carlo
models [1,2]. Complex formation
as an intermediate step in replication (
, besides refining
the model, enhances co-localization of replicase X and templates T and
is shown here to thereby contribute to the evolutionary stability of the
catalyst. Applying the established individual molecule stochastic
PRESS-framework [3], the performances of cooperative
replication with and without intermediate complex formation are compared,
and the beneficial effect of complex formation as enhancing stability is
studied numerically under various conditions. The results obtained are of
value for studies of prebiotic evolution, but also point towards a possible
mechanism for stabilizing replication systems in adaptive molecular
engineering.
PACS: 87.16.Ac – Theory and modeling; computer simulation / 87.23.Cc – Population dynamics and ecological pattern formation / 87.23.Kg – Dynamics of evolution
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag, 2004
