Evolutionary stabilization of generous replicases by complex formation
Fraunhofer – Biomolecular Information Processing Schloss Birlinghoven, St. Augustin 53754, Germany
Corresponding author: a firstname.lastname@example.org
Published online: 20 April 2004
The importance of spatial organization for the evolutionary stability of trans-acting replicase systems (, where T is a general member of a combinatorial family including the special catalyst X, is now well established, by analytical and Monte Carlo models [1,2]. Complex formation as an intermediate step in replication (, besides refining the model, enhances co-localization of replicase X and templates T and is shown here to thereby contribute to the evolutionary stability of the catalyst. Applying the established individual molecule stochastic PRESS-framework , the performances of cooperative replication with and without intermediate complex formation are compared, and the beneficial effect of complex formation as enhancing stability is studied numerically under various conditions. The results obtained are of value for studies of prebiotic evolution, but also point towards a possible mechanism for stabilizing replication systems in adaptive molecular engineering.
PACS: 87.16.Ac – Theory and modeling; computer simulation / 87.23.Cc – Population dynamics and ecological pattern formation / 87.23.Kg – Dynamics of evolution
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag, 2004