Vectorial representation of single- and multi-domain protein folds
Institut für Festkörperphysik, Technische Universität Darmstadt, Hochschulstr. 6-8, 64289, Darmstadt, Germany
Corresponding author: a firstname.lastname@example.org
Revised: 9 October 2006
Published online: 8 December 2006
We discuss a vectorial representation applicable to both single- and multi-domain protein folds. This generalized vectorial representation is essentially identical to the previously described vectorial representation for single-domain proteins folds when applied to these, but allows for the additional consistent representation of multi-domain structures. We show that the generalized vectorial representation enables the accurate analytical prediction of site-specific amino acid distributions for both single- and multi-domain protein folds, similarly as the previously described vectorial representation does for single-domain folds.
PACS: 87.14.Ee – Proteins / 87.15.Cc – Folding and sequence analysis / 87.15.Aa – Theory and modeling; computer simulation
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag, 2006