https://doi.org/10.1140/epjb/e2013-30676-4
Regular Article
Optimization of the bio-functionalized area of magnetic biosensors*
1
L-NESS and CNISM, Dipartimento di Fisica, Politecnico di
Milano, Via Anzani
42, 22100
Como,
Italy
2
Istituto di Chimica del Riconoscimento Molecolare,
CNR, Via Mario Bianco
9, 20131
Milan,
Italy
a e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Received:
24
July
2012
Received in final form:
4
March
2013
Published online:
10
June
2013
Abstract
In this work, calculations and preliminary experimental data for determining the optimal condition for the selective bio-functionalization of magnetic tunneling junction (MTJ)-based biosensors are presented. Results on the detection of biomolecular recognition events employing MTJ-based sensor and magnetic beads are presented and interpreted through calculations, taking into account the dependence of the signal on the distribution of the beads with respect to the sensor. Furthermore, it is demonstrated by calculations that a significant increase in the sensor sensitivity and quantification capability can be achieved by selectively bio-functionalizing an area which corresponds to the sensor active area.
Contribution to the Topical Issue “New Trends in Magnetism and Magnetic Materials”, edited by Francesca Casoli, Massimo Solzi and Paola Tiberto.
© EDP Sciences, Società Italiana di Fisica and Springer-Verlag, 2013
